Observations on the deprotection of pinanediol and pinacol boronate esters via fluorinated intermediates.

نویسندگان

  • Steven R Inglis
  • Esther C Y Woon
  • Amber L Thompson
  • Christopher J Schofield
چکیده

Methods for the deprotection of pinanediol and pinacol esters of various boronic acids via fluoroborane intermediates were evaluated. Treatment of the boronate esters with potassium hydrogen difluoride normally gives trifluoroborate salts; in the case of alpha-amido alkyl or o-amido phenyl boronate esters, aqueous workup gives difluoroboranes. Procedures for transformation of both trifluoroborates and difluoroboranes to free boronic acids are described.

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عنوان ژورنال:
  • The Journal of organic chemistry

دوره 75 2  شماره 

صفحات  -

تاریخ انتشار 2010